Main variables;No. of employees;Total No. of companies carrying out R&D in Biotechnology;Fewer than 250 employees;1.095 No. of companies carrying out R&D in Biotechnology;250 or more employees;103 No. of companies carrying out R&D in Biotechnology;Total 2019;1.198 %Companies according to biotechnology used: Genetic code;Fewer than 250 employees;32,4 %Companies according to biotechnology used: Genetic code;250 or more employees;42,9 %Companies according to biotechnology used: Genetic code;Total 2019;33,3 %Companies according to biotechnology used: Functional units;Fewer than 250 employees;38,5 %Companies according to biotechnology used: Functional units;250 or more employees;54,6 %Companies according to biotechnology used: Functional units;Total 2019;39,8 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;Fewer than 250 employees;23,2 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;250 or more employees;35,1 %Companies according to biotechnology used: Cellular and tissue culturing and engineering;Total 2019;24,2 %Companies according to biotechnology used: Bioprocesses;Fewer than 250 employees;48 %Companies according to biotechnology used: Bioprocesses;250 or more employees;66,9 %Companies according to biotechnology used: Bioprocesses;Total 2019;49,6 %Companies according to biotechnology used: Sub-cellular organisms;Fewer than 250 employees;6 %Companies according to biotechnology used: Sub-cellular organisms;250 or more employees;13,9 %Companies according to biotechnology used: Sub-cellular organisms;Total 2019;6,7 %Companies according to biotechnology used: Bio-computing;Fewer than 250 employees;23,9 %Companies according to biotechnology used: Bio-computing;250 or more employees;23,9 %Companies according to biotechnology used: Bio-computing;Total 2019;23,9 %Companies according to biotechnology used: Nanobiotechnology;Fewer than 250 employees;11,1 %Companies according to biotechnology used: Nanobiotechnology;250 or more employees;11,8 %Companies according to biotechnology used: Nanobiotechnology;Total 2019;11,2 %Companies according to biotechnology used: Other;Fewer than 250 employees;15,3 %Companies according to biotechnology used: Other;250 or more employees;6,9 %Companies according to biotechnology used: Other;Total 2019;14,6 Companies in which biotechnology activities are: Main and/or exclusive;Fewer than 250 employees;616 Companies in which biotechnology activities are: Main and/or exclusive;250 or more employees;28 Companies in which biotechnology activities are: Main and/or exclusive;Total 2019;644 Companies in which biotechnology activities are: A secondary line of business;Fewer than 250 employees;155 Companies in which biotechnology activities are: A secondary line of business;250 or more employees;16 Companies in which biotechnology activities are: A secondary line of business;Total 2019;171 Companies in which biotechnology activities are: A tool necessary for production;Fewer than 250 employees;324 Companies in which biotechnology activities are: A tool necessary for production;250 or more employees;59 Companies in which biotechnology activities are: A tool necessary for production;Total 2019;383 %Company by field(s) of ultimate application of biotechnology use: Human Health;Fewer than 250 employees;47,5 %Company by field(s) of ultimate application of biotechnology use: Human Health;250 or more employees;44,8 %Company by field(s) of ultimate application of biotechnology use: Human Health;Total 2019;47,3 %Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;Fewer than 250 employees;20,3 %Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;250 or more employees;9,9 %Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture;Total 2019;19,4 %Company by field(s) of ultimate application of biotechnology use: Food products;Fewer than 250 employees;32,1 %Company by field(s) of ultimate application of biotechnology use: Food products;250 or more employees;37,2 %Company by field(s) of ultimate application of biotechnology use: Food products;Total 2019;32,5 %Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production;Fewer than 250 employees;24,4 %Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production;250 or more employees;20,9 %Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production;Total 2019;24,1 %Company by field(s) of ultimate application of biotechnology use: Environment;Fewer than 250 employees;14,7 %Company by field(s) of ultimate application of biotechnology use: Environment;250 or more employees;17,6 %Company by field(s) of ultimate application of biotechnology use: Environment;Total 2019;14,9 %Company by field(s) of ultimate application of biotechnology use: Industry;Fewer than 250 employees;13,1 %Company by field(s) of ultimate application of biotechnology use: Industry;250 or more employees;9,9 %Company by field(s) of ultimate application of biotechnology use: Industry;Total 2019;12,8 Personnel in R&D in biotechnology (no. of persons);Fewer than 250 employees;9.761 Personnel in R&D in biotechnology (no. of persons);250 or more employees;3.853 Personnel in R&D in biotechnology (no. of persons);Total 2019;13.615 Personnel in R&D in biotechnology (no. of persons): Researchers;Fewer than 250 employees;5.539 Personnel in R&D in biotechnology (no. of persons): Researchers;250 or more employees;1.898 Personnel in R&D in biotechnology (no. of persons): Researchers;Total 2019;7.436 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants;Fewer than 250 employees;4.223 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants;250 or more employees;1.956 Personnel in R&D in biotechnology (no. of persons): Technicians and assistants;Total 2019;6.178 Personnel in R&D in biotechnology (no. of persons): women;Fewer than 250 employees;5.266 Personnel in R&D in biotechnology (no. of persons): women;250 or more employees;2.373 Personnel in R&D in biotechnology (no. of persons): women;Total 2019;7.639 Personnel in R&D in biotechnology (no. of persons): (women) Researchers;Fewer than 250 employees;2.968 Personnel in R&D in biotechnology (no. of persons): (women) Researchers;250 or more employees;1.127 Personnel in R&D in biotechnology (no. of persons): (women) Researchers;Total 2019;4.095 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants;Fewer than 250 employees;2.298 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants;250 or more employees;1.246 Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants;Total 2019;3.544 Personnel in R&D in biotechnology (FTE);Fewer than 250 employees;6.635,9 Personnel in R&D in biotechnology (FTE);250 or more employees;2.729,4 Personnel in R&D in biotechnology (FTE);Total 2019;9.365,2 Personnel in R&D in biotechnology (FTE): Researchers;Fewer than 250 employees;4.020,1 Personnel in R&D in biotechnology (FTE): Researchers;250 or more employees;1.390,4 Personnel in R&D in biotechnology (FTE): Researchers;Total 2019;5.410,6 Personnel in R&D in biotechnology (FTE): Technicians and assistants;Fewer than 250 employees;2.615,7 Personnel in R&D in biotechnology (FTE): Technicians and assistants;250 or more employees;1.338,9 Personnel in R&D in biotechnology (FTE): Technicians and assistants;Total 2019;3.954,6 Personnel in R&D in biotechnology (FTE): women;Fewer than 250 employees;3.632,6 Personnel in R&D in biotechnology (FTE): women;250 or more employees;1.753,2 Personnel in R&D in biotechnology (FTE): women;Total 2019;5.385,8 Personnel in R&D in biotechnology (FTE): (women) Researchers;Fewer than 250 employees;2.192,4 Personnel in R&D in biotechnology (FTE): (women) Researchers;250 or more employees;840,5 Personnel in R&D in biotechnology (FTE): (women) Researchers;Total 2019;3.032,9 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants;Fewer than 250 employees;1.440,2 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants;250 or more employees;912,6 Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants;Total 2019;2.352,9 Internal expenditure on R&D (thousands of euros);Fewer than 250 employees;677.192 Internal expenditure on R&D (thousands of euros);250 or more employees;263.038 Internal expenditure on R&D (thousands of euros);Total 2019;940.230 1) By nature of the expense: Current expenses;Fewer than 250 employees;626.080 1) By nature of the expense: Current expenses;250 or more employees;245.733 1) By nature of the expense: Current expenses;Total 2019;871.813 1.1) Remuneration to researchers;Fewer than 250 employees;200.684 1.1) Remuneration to researchers;250 or more employees;84.252 1.1) Remuneration to researchers;Total 2019;284.936 1.2) Remuneration to technicians and assistants;Fewer than 250 employees;87.267 1.2) Remuneration to technicians and assistants;250 or more employees;60.987 1.2) Remuneration to technicians and assistants;Total 2019;148.254 1.3) Other current expenses;Fewer than 250 employees;338.128 1.3) Other current expenses;250 or more employees;100.494 1.3) Other current expenses;Total 2019;438.623 2) By nature of the expense: Capital expenses;Fewer than 250 employees;51.113 2) By nature of the expense: Capital expenses;250 or more employees;17.304 2) By nature of the expense: Capital expenses;Total 2019;68.417 2.1) Land and buildings;Fewer than 250 employees;8.402 2.1) Land and buildings;250 or more employees;3.361 2.1) Land and buildings;Total 2019;11.763 2.2) Equipment and instruments;Fewer than 250 employees;26.572 2.2) Equipment and instruments;250 or more employees;13.069 2.2) Equipment and instruments;Total 2019;39.641 2.3) Acquisition of specific R&D software;Fewer than 250 employees;2.155 2.3) Acquisition of specific R&D software;250 or more employees;676 2.3) Acquisition of specific R&D software;Total 2019;2.831 2.4) Otros productos de propiedad intelectual específicos para I+D;Fewer than 250 employees;13.985 2.4) Otros productos de propiedad intelectual específicos para I+D;250 or more employees;199 2.4) Otros productos de propiedad intelectual específicos para I+D;Total 2019;14.183 1.1) By origin of the funds: Own funds;Fewer than 250 employees;427.439 1.1) By origin of the funds: Own funds;250 or more employees;149.847 1.1) By origin of the funds: Own funds;Total 2019;577.287 1.2) By origin of the funds: From companies;Fewer than 250 employees;104.912 1.2) By origin of the funds: From companies;250 or more employees;37.760 1.2) By origin of the funds: From companies;Total 2019;142.672 1.3) By origin of the funds: Public Administration funds;Fewer than 250 employees;81.268 1.3) By origin of the funds: Public Administration funds;250 or more employees;21.363 1.3) By origin of the funds: Public Administration funds;Total 2019;102.630 1.4) By origin of the funds: From Universities;Fewer than 250 employees;425 1.4) By origin of the funds: From Universities;250 or more employees;32 1.4) By origin of the funds: From Universities;Total 2019;457 1.5) By origin of the funds: From non profit private institutions;Fewer than 250 employees;2.098 1.5) By origin of the funds: From non profit private institutions;250 or more employees;7.533 1.5) By origin of the funds: From non profit private institutions;Total 2019;9.631 1.6) By origin of the funds: Foreign funds;Fewer than 250 employees;61.050 1.6) By origin of the funds: Foreign funds;250 or more employees;46.503 1.6) By origin of the funds: Foreign funds;Total 2019;107.553 Purchase of R&D services in biotechnology (thousands of euros);Fewer than 250 employees;64.508 Purchase of R&D services in biotechnology (thousands of euros);250 or more employees;50.330 Purchase of R&D services in biotechnology (thousands of euros);Total 2019;114.839 Purchase of R&D services in biotechnology (thousands of euros): In Spain;Fewer than 250 employees;27.696 Purchase of R&D services in biotechnology (thousands of euros): In Spain;250 or more employees;41.562 Purchase of R&D services in biotechnology (thousands of euros): In Spain;Total 2019;69.258 Purchase of R&D services in biotechnology (thousands of euros): Abroad;Fewer than 250 employees;36.813 Purchase of R&D services in biotechnology (thousands of euros): Abroad;250 or more employees;8.768 Purchase of R&D services in biotechnology (thousands of euros): Abroad;Total 2019;45.581 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;Fewer than 250 employees;43,3 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;250 or more employees;26,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to capital;Total 2019;41,8 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;Fewer than 250 employees;12,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;250 or more employees;11,1 %Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information;Total 2019;12 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;Fewer than 250 employees;13,3 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;250 or more employees;11 %Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources;Total 2019;13,1 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;Fewer than 250 employees;10,6 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;250 or more employees;11,2 %Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain;Total 2019;10,7 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;Fewer than 250 employees;15,8 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;250 or more employees;8,1 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets;Total 2019;15,1 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels;Fewer than 250 employees;16,5 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels;250 or more employees;7 %Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels;Total 2019;15,7 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;Fewer than 250 employees;16,1 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;250 or more employees;13,5 %Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception;Total 2019;15,9 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;Fewer than 250 employees;38 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;250 or more employees;31 %Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements;Total 2019;37 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;Fewer than 250 employees;51,7 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;250 or more employees;40,1 %Companies that consider the following obstacles as very important considering biotechnology development: Time / cost;Total 2019;50,7 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;Fewer than 250 employees;19,7 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;250 or more employees;11,9 %Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting;Total 2019;19 % Companies that have requested biotechnology patents in Biotechnology;Fewer than 250 employees;18,3 % Companies that have requested biotechnology patents in Biotechnology;250 or more employees;18,6 % Companies that have requested biotechnology patents in Biotechnology;Total 2019;18,3 Number of patents requested;Fewer than 250 employees;554 Number of patents requested;250 or more employees;89 Number of patents requested;Total 2019;643 % Companies with income of an international origin related to biotechnological activities;Fewer than 250 employees;25,2 % Companies with income of an international origin related to biotechnological activities;250 or more employees;16,1 % Companies with income of an international origin related to biotechnological activities;Total 2019;24,4 % Turnover representing income of an international origin related to biotechnological activities;Fewer than 250 employees;7,1 % Turnover representing income of an international origin related to biotechnological activities;250 or more employees;0,9 % Turnover representing income of an international origin related to biotechnological activities;Total 2019;1,6 % Income of an international origin related to biotechnological activities distributed in: Income received from the EU;Fewer than 250 employees;39,7 % Income of an international origin related to biotechnological activities distributed in: Income received from the EU;250 or more employees;70,9 % Income of an international origin related to biotechnological activities distributed in: Income received from the EU;Total 2019;55,7 % Income of an international origin related to biotechnological activities distributed in: Income received from other countries;Fewer than 250 employees;60,3 % Income of an international origin related to biotechnological activities distributed in: Income received from other countries;250 or more employees;29,1 % Income of an international origin related to biotechnological activities distributed in: Income received from other countries;Total 2019;44,3 % Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services;Fewer than 250 employees;90,9 % Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services;250 or more employees;50,7 % Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services;Total 2019;70,3 % Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Fewer than 250 employees;4,9 % Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;250 or more employees;41,9 % Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Total 2019;23,9 % Income of an international origin related with activities according to the classification: Operating source abroad;Fewer than 250 employees;3,2 % Income of an international origin related with activities according to the classification: Operating source abroad;250 or more employees;7,2 % Income of an international origin related with activities according to the classification: Operating source abroad;Total 2019;5,3 % Income of an international origin related with activities according to the classification: Other;Fewer than 250 employees;1,1 % Income of an international origin related with activities according to the classification: Other;250 or more employees;0,1 % Income of an international origin related with activities according to the classification: Other;Total 2019;0,6