Main variables	No. of employees	Total
No. of companies carrying out R&D in Biotechnology	Fewer than 250 employees	1.095
No. of companies carrying out R&D in Biotechnology	250 or more employees	103
No. of companies carrying out R&D in Biotechnology	Total 2019	1.198
%Companies according to biotechnology used: Genetic code	Fewer than 250 employees	32,4
%Companies according to biotechnology used: Genetic code	250 or more employees	42,9
%Companies according to biotechnology used: Genetic code	Total 2019	33,3
%Companies according to biotechnology used: Functional units	Fewer than 250 employees	38,5
%Companies according to biotechnology used: Functional units	250 or more employees	54,6
%Companies according to biotechnology used: Functional units	Total 2019	39,8
%Companies according to biotechnology used: Cellular and tissue culturing and engineering	Fewer than 250 employees	23,2
%Companies according to biotechnology used: Cellular and tissue culturing and engineering	250 or more employees	35,1
%Companies according to biotechnology used: Cellular and tissue culturing and engineering	Total 2019	24,2
%Companies according to biotechnology used: Bioprocesses	Fewer than 250 employees	48
%Companies according to biotechnology used: Bioprocesses	250 or more employees	66,9
%Companies according to biotechnology used: Bioprocesses	Total 2019	49,6
%Companies according to biotechnology used: Sub-cellular organisms	Fewer than 250 employees	6
%Companies according to biotechnology used: Sub-cellular organisms	250 or more employees	13,9
%Companies according to biotechnology used: Sub-cellular organisms	Total 2019	6,7
%Companies according to biotechnology used: Bio-computing	Fewer than 250 employees	23,9
%Companies according to biotechnology used: Bio-computing	250 or more employees	23,9
%Companies according to biotechnology used: Bio-computing	Total 2019	23,9
%Companies according to biotechnology used: Nanobiotechnology	Fewer than 250 employees	11,1
%Companies according to biotechnology used: Nanobiotechnology	250 or more employees	11,8
%Companies according to biotechnology used: Nanobiotechnology	Total 2019	11,2
%Companies according to biotechnology used: Other	Fewer than 250 employees	15,3
%Companies according to biotechnology used: Other	250 or more employees	6,9
%Companies according to biotechnology used: Other	Total 2019	14,6
Companies in which biotechnology activities are: Main and/or exclusive	Fewer than 250 employees	616
Companies in which biotechnology activities are: Main and/or exclusive	250 or more employees	28
Companies in which biotechnology activities are: Main and/or exclusive	Total 2019	644
Companies in which biotechnology activities are: A secondary line of business	Fewer than 250 employees	155
Companies in which biotechnology activities are: A secondary line of business	250 or more employees	16
Companies in which biotechnology activities are: A secondary line of business	Total 2019	171
Companies in which biotechnology activities are: A tool necessary for production	Fewer than 250 employees	324
Companies in which biotechnology activities are: A tool necessary for production	250 or more employees	59
Companies in which biotechnology activities are: A tool necessary for production	Total 2019	383
%Company by field(s) of ultimate application of biotechnology use: Human Health	Fewer than 250 employees	47,5
%Company by field(s) of ultimate application of biotechnology use: Human Health	250 or more employees	44,8
%Company by field(s) of ultimate application of biotechnology use: Human Health	Total 2019	47,3
%Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture	Fewer than 250 employees	20,3
%Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture	250 or more employees	9,9
%Company by field(s) of ultimate application of biotechnology use: Animal Health and Aquaculture	Total 2019	19,4
%Company by field(s) of ultimate application of biotechnology use: Food products	Fewer than 250 employees	32,1
%Company by field(s) of ultimate application of biotechnology use: Food products	250 or more employees	37,2
%Company by field(s) of ultimate application of biotechnology use: Food products	Total 2019	32,5
%Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production	Fewer than 250 employees	24,4
%Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production	250 or more employees	20,9
%Company by field(s) of ultimate application of biotechnology use: Agriculture and forest production	Total 2019	24,1
%Company by field(s) of ultimate application of biotechnology use: Environment	Fewer than 250 employees	14,7
%Company by field(s) of ultimate application of biotechnology use: Environment	250 or more employees	17,6
%Company by field(s) of ultimate application of biotechnology use: Environment	Total 2019	14,9
%Company by field(s) of ultimate application of biotechnology use: Industry	Fewer than 250 employees	13,1
%Company by field(s) of ultimate application of biotechnology use: Industry	250 or more employees	9,9
%Company by field(s) of ultimate application of biotechnology use: Industry	Total 2019	12,8
Personnel in R&D in biotechnology (no. of persons)	Fewer than 250 employees	9.761
Personnel in R&D in biotechnology (no. of persons)	250 or more employees	3.853
Personnel in R&D in biotechnology (no. of persons)	Total 2019	13.615
Personnel in R&D in biotechnology (no. of persons): Researchers	Fewer than 250 employees	5.539
Personnel in R&D in biotechnology (no. of persons): Researchers	250 or more employees	1.898
Personnel in R&D in biotechnology (no. of persons): Researchers	Total 2019	7.436
Personnel in R&D in biotechnology (no. of persons): Technicians and assistants	Fewer than 250 employees	4.223
Personnel in R&D in biotechnology (no. of persons): Technicians and assistants	250 or more employees	1.956
Personnel in R&D in biotechnology (no. of persons): Technicians and assistants	Total 2019	6.178
Personnel in R&D in biotechnology (no. of persons): women	Fewer than 250 employees	5.266
Personnel in R&D in biotechnology (no. of persons): women	250 or more employees	2.373
Personnel in R&D in biotechnology (no. of persons): women	Total 2019	7.639
Personnel in R&D in biotechnology (no. of persons): (women) Researchers	Fewer than 250 employees	2.968
Personnel in R&D in biotechnology (no. of persons): (women) Researchers	250 or more employees	1.127
Personnel in R&D in biotechnology (no. of persons): (women) Researchers	Total 2019	4.095
Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants	Fewer than 250 employees	2.298
Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants	250 or more employees	1.246
Personnel in R&D in biotechnology (no. of persons): (women) Technicians and assistants	Total 2019	3.544
Personnel in R&D in biotechnology (FTE)	Fewer than 250 employees	6.635,9
Personnel in R&D in biotechnology (FTE)	250 or more employees	2.729,4
Personnel in R&D in biotechnology (FTE)	Total 2019	9.365,2
Personnel in R&D in biotechnology (FTE): Researchers	Fewer than 250 employees	4.020,1
Personnel in R&D in biotechnology (FTE): Researchers	250 or more employees	1.390,4
Personnel in R&D in biotechnology (FTE): Researchers	Total 2019	5.410,6
Personnel in R&D in biotechnology (FTE): Technicians and assistants	Fewer than 250 employees	2.615,7
Personnel in R&D in biotechnology (FTE): Technicians and assistants	250 or more employees	1.338,9
Personnel in R&D in biotechnology (FTE): Technicians and assistants	Total 2019	3.954,6
Personnel in R&D in biotechnology (FTE): women	Fewer than 250 employees	3.632,6
Personnel in R&D in biotechnology (FTE): women	250 or more employees	1.753,2
Personnel in R&D in biotechnology (FTE): women	Total 2019	5.385,8
Personnel in R&D in biotechnology (FTE): (women) Researchers	Fewer than 250 employees	2.192,4
Personnel in R&D in biotechnology (FTE): (women) Researchers	250 or more employees	840,5
Personnel in R&D in biotechnology (FTE): (women) Researchers	Total 2019	3.032,9
Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants	Fewer than 250 employees	1.440,2
Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants	250 or more employees	912,6
Personnel in R&D in biotechnology (FTE): (women) Technicians and assistants	Total 2019	2.352,9
Internal expenditure on R&D (thousands of euros)	Fewer than 250 employees	677.192
Internal expenditure on R&D (thousands of euros)	250 or more employees	263.038
Internal expenditure on R&D (thousands of euros)	Total 2019	940.230
1) By nature of the expense: Current expenses	Fewer than 250 employees	626.080
1) By nature of the expense: Current expenses	250 or more employees	245.733
1) By nature of the expense: Current expenses	Total 2019	871.813
1.1) Remuneration to researchers	Fewer than 250 employees	200.684
1.1) Remuneration to researchers	250 or more employees	84.252
1.1) Remuneration to researchers	Total 2019	284.936
1.2) Remuneration to technicians and assistants	Fewer than 250 employees	87.267
1.2) Remuneration to technicians and assistants	250 or more employees	60.987
1.2) Remuneration to technicians and assistants	Total 2019	148.254
1.3) Other current expenses	Fewer than 250 employees	338.128
1.3) Other current expenses	250 or more employees	100.494
1.3) Other current expenses	Total 2019	438.623
2) By nature of the expense: Capital expenses	Fewer than 250 employees	51.113
2) By nature of the expense: Capital expenses	250 or more employees	17.304
2) By nature of the expense: Capital expenses	Total 2019	68.417
2.1) Land and buildings	Fewer than 250 employees	8.402
2.1) Land and buildings	250 or more employees	3.361
2.1) Land and buildings	Total 2019	11.763
2.2) Equipment and instruments	Fewer than 250 employees	26.572
2.2) Equipment and instruments	250 or more employees	13.069
2.2) Equipment and instruments	Total 2019	39.641
2.3) Acquisition of specific R&D software	Fewer than 250 employees	2.155
2.3) Acquisition of specific R&D software	250 or more employees	676
2.3) Acquisition of specific R&D software	Total 2019	2.831
2.4) Otros productos de propiedad intelectual específicos para I+D	Fewer than 250 employees	13.985
2.4) Otros productos de propiedad intelectual específicos para I+D	250 or more employees	199
2.4) Otros productos de propiedad intelectual específicos para I+D	Total 2019	14.183
1.1) By origin of the funds: Own funds	Fewer than 250 employees	427.439
1.1) By origin of the funds: Own funds	250 or more employees	149.847
1.1) By origin of the funds: Own funds	Total 2019	577.287
1.2) By origin of the funds: From companies	Fewer than 250 employees	104.912
1.2) By origin of the funds: From companies	250 or more employees	37.760
1.2) By origin of the funds: From companies	Total 2019	142.672
1.3) By origin of the funds: Public Administration funds	Fewer than 250 employees	81.268
1.3) By origin of the funds: Public Administration funds	250 or more employees	21.363
1.3) By origin of the funds: Public Administration funds	Total 2019	102.630
1.4) By origin of the funds: From Universities	Fewer than 250 employees	425
1.4) By origin of the funds: From Universities	250 or more employees	32
1.4) By origin of the funds: From Universities	Total 2019	457
1.5) By origin of the funds: From non profit private institutions	Fewer than 250 employees	2.098
1.5) By origin of the funds: From non profit private institutions	250 or more employees	7.533
1.5) By origin of the funds: From non profit private institutions	Total 2019	9.631
1.6) By origin of the funds: Foreign funds	Fewer than 250 employees	61.050
1.6) By origin of the funds: Foreign funds	250 or more employees	46.503
1.6) By origin of the funds: Foreign funds	Total 2019	107.553
Purchase of R&D services in biotechnology (thousands of euros)	Fewer than 250 employees	64.508
Purchase of R&D services in biotechnology (thousands of euros)	250 or more employees	50.330
Purchase of R&D services in biotechnology (thousands of euros)	Total 2019	114.839
Purchase of R&D services in biotechnology (thousands of euros): In Spain	Fewer than 250 employees	27.696
Purchase of R&D services in biotechnology (thousands of euros): In Spain	250 or more employees	41.562
Purchase of R&D services in biotechnology (thousands of euros): In Spain	Total 2019	69.258
Purchase of R&D services in biotechnology (thousands of euros): Abroad	Fewer than 250 employees	36.813
Purchase of R&D services in biotechnology (thousands of euros): Abroad	250 or more employees	8.768
Purchase of R&D services in biotechnology (thousands of euros): Abroad	Total 2019	45.581
%Companies that consider the following obstacles as very important considering biotechnology development: Access to capital	Fewer than 250 employees	43,3
%Companies that consider the following obstacles as very important considering biotechnology development: Access to capital	250 or more employees	26,1
%Companies that consider the following obstacles as very important considering biotechnology development: Access to capital	Total 2019	41,8
%Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information	Fewer than 250 employees	12,1
%Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information	250 or more employees	11,1
%Companies that consider the following obstacles as very important considering biotechnology development: Access to technology / information	Total 2019	12
%Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources	Fewer than 250 employees	13,3
%Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources	250 or more employees	11
%Companies that consider the following obstacles as very important considering biotechnology development: Access to human resources	Total 2019	13,1
%Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain	Fewer than 250 employees	10,6
%Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain	250 or more employees	11,2
%Companies that consider the following obstacles as very important considering biotechnology development: Disconnection from the value chain	Total 2019	10,7
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets	Fewer than 250 employees	15,8
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets	250 or more employees	8,1
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of access to international markets	Total 2019	15,1
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels	Fewer than 250 employees	16,5
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels	250 or more employees	7
%Companies that consider the following obstacles as very important considering biotechnology development: Lack of distribution and sales channels	Total 2019	15,7
%Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception	Fewer than 250 employees	16,1
%Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception	250 or more employees	13,5
%Companies that consider the following obstacles as very important considering biotechnology development: Acceptance / public perception	Total 2019	15,9
%Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements	Fewer than 250 employees	38
%Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements	250 or more employees	31
%Companies that consider the following obstacles as very important considering biotechnology development: Legal and regulatory requirements	Total 2019	37
%Companies that consider the following obstacles as very important considering biotechnology development: Time / cost	Fewer than 250 employees	51,7
%Companies that consider the following obstacles as very important considering biotechnology development: Time / cost	250 or more employees	40,1
%Companies that consider the following obstacles as very important considering biotechnology development: Time / cost	Total 2019	50,7
%Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting	Fewer than 250 employees	19,7
%Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting	250 or more employees	11,9
%Companies that consider the following obstacles as very important considering biotechnology development: Difficulty accessing patenting	Total 2019	19
% Companies that have requested biotechnology patents in Biotechnology	Fewer than 250 employees	18,3
% Companies that have requested biotechnology patents in Biotechnology	250 or more employees	18,6
% Companies that have requested biotechnology patents in Biotechnology	Total 2019	18,3
Number of patents requested	Fewer than 250 employees	554
Number of patents requested	250 or more employees	89
Number of patents requested	Total 2019	643
% Companies with income of an international origin related to biotechnological activities	Fewer than 250 employees	25,2
% Companies with income of an international origin related to biotechnological activities	250 or more employees	16,1
% Companies with income of an international origin related to biotechnological activities	Total 2019	24,4
% Turnover representing income of an international origin related to biotechnological activities	Fewer than 250 employees	7,1
% Turnover representing income of an international origin related to biotechnological activities	250 or more employees	0,9
% Turnover representing income of an international origin related to biotechnological activities	Total 2019	1,6
% Income of an international origin related to biotechnological activities distributed in: Income received from the EU	Fewer than 250 employees	39,7
% Income of an international origin related to biotechnological activities distributed in: Income received from the EU	250 or more employees	70,9
% Income of an international origin related to biotechnological activities distributed in: Income received from the EU	Total 2019	55,7
% Income of an international origin related to biotechnological activities distributed in: Income received from other countries	Fewer than 250 employees	60,3
% Income of an international origin related to biotechnological activities distributed in: Income received from other countries	250 or more employees	29,1
% Income of an international origin related to biotechnological activities distributed in: Income received from other countries	Total 2019	44,3
% Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services	Fewer than 250 employees	90,9
% Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services	250 or more employees	50,7
% Income of an international origin related to biotechnological activities by classification: Internacional trade in products and services	Total 2019	70,3
% Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain	Fewer than 250 employees	4,9
% Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain	250 or more employees	41,9
% Income of an international origin related to biotechnological activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain	Total 2019	23,9
% Income of an international origin related with activities according to the classification: Operating source abroad	Fewer than 250 employees	3,2
% Income of an international origin related with activities according to the classification: Operating source abroad	250 or more employees	7,2
% Income of an international origin related with activities according to the classification: Operating source abroad	Total 2019	5,3
% Income of an international origin related with activities according to the classification: Other	Fewer than 250 employees	1,1
% Income of an international origin related with activities according to the classification: Other	250 or more employees	0,1
% Income of an international origin related with activities according to the classification: Other	Total 2019	0,6